Description
About Epitalon
Epitalon, also known as Epithalon, is a synthetic tetrapeptide composed of the four-amino-acid sequence Ala-Glu-Asp-Gly, commonly abbreviated as AEDG.
It is primarily studied in experimental models of cellular ageing, particularly research involving telomeres and telomerase. Telomeres are protective regions at the ends of chromosomes that generally become shorter as cells repeatedly divide, while telomerase is an enzyme capable of helping maintain or extend them.
In cultured human cells, researchers have reported increased telomerase activity, telomere elongation and extended replicative capacity following Epitalon exposure under specific experimental conditions.
These findings have made Epitalon particularly relevant to research examining how telomere maintenance relates to cellular ageing and the point at which cells lose the capacity to continue dividing.
Separate experimental research has examined Epitalon in relation to gene expression, chromatin organisation and circadian or neuroendocrine signalling, broadening its research context beyond telomere biology alone.
Pronoia supplies Epitalon in a higher-total-content 50mg lyophilised research format with batch traceability and supporting documentation available for the supplied material.
Product Specification
Product: Epitalon
Alternative name: Epithalon
Strength: 50mg
Peptide class: Synthetic tetrapeptide
Peptide length: 4 amino acids
Sequence: Ala-Glu-Asp-Gly
Sequence notation: AEDG
Research focus: Telomerase activity, telomere biology, replicative cellular ageing, gene regulation and circadian biology
Form: Lyophilised solid
Pronoia minimum purity standard: ≥99%
Batch traceability: Maintained
SKU: PB-EPI-50
Testing & Batch Documentation
Pronoia maintains a structured quality, testing and traceability process for Epitalon, with supporting documentation retained for the supplied research material.
- Batch-tested research material
- Pronoia minimum accepted purity standard of ≥99%
- Full batch traceability
- Batch-separated and labelled inventory
- Physical inventory routinely reconciled with digital stock records
- Temperature-controlled cold storage
- Certificate of Analysis (COA) and Safety Data Sheet (SDS) documentation available
The applicable Certificate of Analysis should be treated as the authoritative reference for the identity, purity and analytical results reported for an individual batch.
Research Context
Epitalon has been investigated primarily in experimental research examining cellular ageing, telomere maintenance and mechanisms influencing how long cells retain their capacity to divide.
Telomeres are repetitive DNA structures that protect the ends of chromosomes. In many somatic cells they progressively shorten during repeated cell division, eventually contributing to replicative senescence — a state in which cells remain biologically active but no longer continue normal division.
Telomerase is an enzyme capable of adding telomeric DNA and is therefore an important experimental target in research examining telomere maintenance and cellular replicative lifespan.
Early laboratory research using human fibroblasts reported that Epitalon exposure was associated with:
- Expression of the catalytic component of telomerase
- Activation of telomerase enzyme activity
- Elongation of telomeres within cultured cells
Follow-up experiments investigated whether these molecular changes were accompanied by differences in cellular replicative behaviour.
In ageing human fibroblast cultures, control cells eventually lost proliferative capacity, while Epitalon-treated cells showed telomere elongation and continued through approximately 10 additional passages under the experimental conditions used.
These findings made Epitalon particularly relevant to research examining the relationship between telomerase activity, telomere length and replicative cellular ageing.
More recent cell-based research has revisited these mechanisms in additional human cell systems.
Researchers have reported dose-dependent telomere-length extension in normal human fibroblast and epithelial cells following Epitalon exposure, together with increased hTERT expression and telomerase enzyme activity.
hTERT is the catalytic component of telomerase and plays a central role in the enzyme’s ability to extend telomeric DNA. Changes in hTERT expression therefore provide an additional molecular measure through which researchers can investigate telomerase-associated regulation.
Different responses have also been observed across different cell types, including cancer-derived cell lines, highlighting that Epitalon’s effects can depend strongly on the underlying cellular and telomere biology of the experimental system.
Epitalon research extends beyond telomere regulation.
Experimental areas have also included:
- Age-associated gene-expression regulation
- Chromatin organisation and accessibility
- Ribosomal-gene activity
- Cell-cycle and replicative-ageing processes
- Circadian and neuroendocrine regulation
- Melatonin and cortisol-associated biological rhythms
Research using cultured cells from older individuals has examined changes in chromatin organisation and the activity of previously less-accessible genetic regions following Epitalon exposure.
Separate preclinical research in ageing primates has investigated neuroendocrine and circadian effects. Under specific experimental conditions, researchers reported changes in evening or night-time melatonin production and in the daily pattern of cortisol secretion.
Together, these findings broaden the research context surrounding Epitalon from telomere maintenance alone into wider questions concerning cellular ageing, gene regulation and age-associated biological rhythms.
The evidence base nevertheless requires careful interpretation. Much of the foundational Epitalon literature derives from cell-culture and animal research, and the available findings do not establish that the same effects occur across different biological systems.
More recent research adds further experimental evidence to the telomere-related literature, but clinical anti-ageing or lifespan-extending effects in humans have not been established.
The published findings should therefore be interpreted within their specific experimental settings and do not establish clinical efficacy, safety or suitability for human or veterinary use.
Storage & Handling
Epitalon is supplied in lyophilised form and should be stored according to the conditions specified by Pronoia and the applicable batch documentation.
Pronoia stock is maintained in temperature-controlled cold storage and organised by identifiable batch prior to dispatch.
The material should be protected from unnecessary exposure to heat, moisture and light and handled using appropriate laboratory procedures.
Where batch-specific storage or handling information is supplied, that information should take precedence.
UK Delivery
Epitalon is dispatched from Pronoia’s UK stock using tracked delivery.
Current availability and dispatch information are shown directly on the product page, with tracking supplied following dispatch.
Orders are prepared through Pronoia’s established research-product fulfilment process, with applicable delivery conditions remaining subject to Pronoia’s current delivery terms.
Research Use
Epitalon supplied by Pronoia Bio is intended for laboratory research and experimental use only.
It is not supplied for human or veterinary use and should not be treated as a medicine or consumer healthcare product.
Pronoia does not provide dosage, treatment or administration guidance for this research material.
