Description
About 5-Amino-1MQ
5-Amino-1MQ, commonly referring to 5-amino-1-methylquinolinium, is a small-molecule research compound investigated for its ability to inhibit nicotinamide N-methyltransferase (NNMT).
NNMT is an enzyme involved in processing nicotinamide and producing a compound known as 1-MNA. Because this pathway is connected with cellular metabolism, researchers have investigated whether reducing NNMT activity can influence fat-cell behaviour, energy-related processes and wider metabolic regulation.
Published experiments with 5-Amino-1MQ have reported reduced markers of NNMT activity and reduced fat accumulation in cultured fat cells. In mice fed a high-fat diet to produce obesity-related metabolic changes, researchers also observed lower body weight and white fat mass compared with untreated controls.
These findings make 5-Amino-1MQ relevant to research examining how changes in NNMT activity may influence fat storage and metabolic processes.
Pronoia supplies 5-Amino-1MQ in a 50mg research format with batch traceability and supporting documentation available for the supplied material.
Product Specification
Product: 5-Amino-1MQ
Chemical reference: 5-amino-1-methylquinolinium
Specification: 50mg
Compound type: Small molecule (non-peptide)
Research target: Nicotinamide N-methyltransferase (NNMT)
Research focus: Fat-cell and metabolic regulation
Form: Solid research compound
Pronoia minimum purity standard: ≥99%
Batch traceability: Maintained
SKU: PB-1MQ-50
Testing & Batch Documentation
Pronoia maintains a structured quality, testing and traceability process for 5-Amino-1MQ, with supporting documentation retained for the supplied research material.
- Independent third-party analytical testing
- Pronoia minimum accepted purity standard of ≥99%
- Full batch traceability
- Batch-separated and labelled inventory
- Physical inventory routinely reconciled with digital stock records
- Temperature-controlled cold storage
- Certificate of Analysis (COA) and Safety Data Sheet (SDS) documentation available
The Certificate of Analysis should be treated as the authoritative reference for the analytical results reported for an individual batch.
Research Context
Published research has examined 5-Amino-1MQ in laboratory-grown fat cells and preclinical mouse models to investigate how inhibition of NNMT influences cellular metabolism.
In cultured fat-cell experiments, researchers reported:
- Reduced levels of 1-MNA, a molecule produced when NNMT acts on nicotinamide
- Changes in pathways involving NAD⁺ and S-adenosylmethionine (SAM), molecules involved in cellular energy and metabolic regulation
- Reduced accumulation of fat within developing fat cells
Researchers have also studied 5-Amino-1MQ in mice fed a high-fat diet to produce obesity-related metabolic changes. Compared with untreated control animals, published experiments reported:
- Lower body weight
- Reduced white fat mass
- Smaller fat cells
- Changes in metabolic markers including plasma cholesterol
Together, these findings make 5-Amino-1MQ relevant to experimental research investigating how NNMT activity may influence fat-cell behaviour, energy-related metabolism and wider metabolic regulation.
These findings describe results observed within specific laboratory and animal experiments. They do not establish that the same outcomes would occur in other experimental systems or in humans.
Storage & Handling
5-Amino-1MQ is supplied as a solid research compound and should be stored according to the conditions specified by Pronoia and the applicable batch documentation.
Pronoia stock is maintained in temperature-controlled cold storage and organised by identifiable batch prior to dispatch.
The material should be protected from unnecessary environmental exposure and handled using appropriate laboratory procedures.
Where batch-specific storage or handling information is supplied, that information should take precedence.
UK Delivery
5-Amino-1MQ is dispatched from Pronoia’s UK stock using tracked delivery.
Current availability and dispatch information are shown directly on the product page, with tracking supplied following dispatch.
Orders are prepared through Pronoia’s established research-product fulfilment process, with applicable delivery conditions remaining subject to Pronoia’s current delivery terms.
Research Use
5-Amino-1MQ supplied by Pronoia Bio is intended for laboratory research and experimental use only.
It is not supplied for human or veterinary use and should not be treated as a medicine or consumer healthcare product.
Pronoia does not provide dosage, treatment or administration guidance for this research material.
